one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This really is an impurity linked to bortezomib, a proteasome inhibitor Employed in the therapy of several myeloma. Its synthesis or examine is essential for guaranteeing the purity and security of the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-seven): A precursor during the synthesis of abiraterone acetate, a drug Utilized in the procedure of prostate cancer by inhibiting androgen generation.
Imatinib Intermediate (CAS NO. 152460-ten-1): A key compound from the synthesis of imatinib, a drug that targets distinct varieties of most cancers, which includes chronic myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Utilized in the synthesis of docetaxel, a chemotherapy medication that treats various cancers which include breast, lung, and prostate cancer.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, eight): These are generally intermediates within the synthesis of gemcitabine, an anti-cancer drug. Their study is significant for optimizing the manufacturing process and guaranteeing higher purity.
Lapatinib Intermediate (CAS NO. 231278-eighty four-5): Lapatinib is used to treat breast most cancers, and these intermediates are linked to its manufacturing.
Fulvestrant Intermediates: Fulvestrant is really 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide an estrogen receptor antagonist Employed in the therapy of breast most cancers. Many intermediates assist in the synthesis of this drug.
Paclitaxel Facet Chain Acid (CAS NO. 949023-sixteen-nine): This intermediate is used in the synthesis of paclitaxel, a chemotherapy drug powerful in managing cancers which include ovarian, breast, and lung most cancers.
3. Other Notable Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-3): A chemotherapy drug used in the cure of colorectal most cancers and tiny cell lung cancer.
three-Amino-one-hydroxyadamantane (CAS 702-eighty two-nine): This compound is linked to the synthesis of adamantane derivatives, which have numerous apps, which include antiviral Attributes.
Vildagliptin Intermediates: Employed in the creation of vildagliptin, an oral (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4 drug for type two diabetic issues that inhibits the enzyme DPP-four to manage blood sugar concentrations.
four. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-forty eight-one): This compound is involved with the synthesis of varied gluconic acid derivatives, which might be Employed in food stuff, pharmaceutical, and industrial purposes.
Canagliflozin Intermediate two: A precursor during the synthesis of canagliflozin, a medication made use of to deal with variety 2 diabetes by inhibiting sodium-glucose co-transporter two (SGLT2).